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Why So Many People Need 5-MTHF instead of Folic Acid?

release time:2021-09-07

Folic Acid is a synthetic compound that does not exist in nature and has no vitamin activity. It must be metabolized by the enzyme system before it can be used by the body. People who take folic acid through fortification or supplementation usually have unmetabolized folic acid in the blood.

 

In order for folic acid to remove homocysteine, it first must be converted to its active form called L-methylfolate (5-MTHF). 

 

Magnafolate®  is the existing form of folate in human blood circulation, the metabolite of folic acid. It is the only endogenous 5-methyltetrahydrofolate that can cross the blood-brain barrier and the blood-retinal barrier and can directly act as a methyl donor. Without conversion, it can be directly absorbed and utilized. It is the best form of active folate.

 

  • < >Magnafolate® is the patent protected C crystalline L-5-Methyltetrahydrofolate Calcium salt (L-5-MTHF Ca) which is invented by Jinkang Pharma from China in 2012, produced under US Patent No. 9,150,982 B2. The preparation of the Calcium salt and the crystal type C solved the stability problem completely. It has the highest purity more than 99%, and controls some potential risky impurites to the smallest assay.Such as Mercury 0.1ppm, 15 times less than USP standard 1.5ppmJK12A 0.1% , 10 times less than USP standard 1.0%D-5- Methyltetrahydrofolate 0.1%,  10 times less than USP standard 1.0%Importantly, we avoid using the toxic raw material of formaldehyde during production process compared to other marketing  generic L-methylfolate.

 

Now, Magnafolate ® has been well approved in US GRAS, NDI and FDA.