The process of folate metabolism is a key that affects its biological characteristics

Dietary folate, mainly found in liver, cereals, legumes, dark green leafy vegetables, orange fruits and eggs. The main component of dietary folate is a complex mixture of L-5-methyltetrahydrofolate with polyglutamates and monoglutamates. After being ingested into the body, the substance is first hydrolysed by the appropriate hydrolytic enzymes in the body to convert the polyglutamate of dietary folate into monoglutamate before it can be absorbed and utilised.

The main metabolic history of inactive synthetic folic acid in the body is as follows: during absorption in the intestine and during transport to peripheral tissues, synthetic folic acid is reduced by dihydrofolate reductase to dihydrofolate; dihydrofolate continues to be reduced by dihydrofolate reductase to tetrahydrofolate: tetrahydrofolate is then converted to 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate is finally reduced by methylenetetrahydrofolate 5,10-methylenetetrahydrofolate is finally catalyzed by methylenetetrahydrofolate reductase (MTHFR) to form L-5-methyltetrahydrofolate, which is involved in two key metabolic pathways: methylation processes and DNA synthesis. It is through these metabolic processes that inactive synthetic folic acid is converted into biologically active 5-methyltetrahydrofolate.

Therefore we recommend calcium L-5-methyltetrahydrofolate:
Magnafolate is the unique patent protected C crystalline L-5-Methyltetrahydrofolate Calcium salt (L-5-MTHF Ca) which can get the purest and most stable bio-active folate.
Magnafolate can be absorbed directly, no metabolism, applied for all people.