l-5-methyltetrahydrofolate belongs to the category of "nutritional supplements" and is mainly used for folate deficiency (low levels of folate) and anaemia (lack of red blood cells). It is useful for low folate levels due to poor diet, pregnancy, alcoholism and other diseases.

l-5-Methyltetrahydrofolate and l-methylfolate are, to some extent, different names for the same product. The distinction is based on the CAS number of l-5-methyltetrahydrofolate and l-methylfolate.

Magnafolate® is the patent protected C crystalline L-5-Methyltetrahydrofolate Calcium(L-5-MTHF Ca) which is invented by Jinkang Pharma from China in 2012.